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Under normal conditions, estrogen signals the hypothalamus to reduce the release of gonadotropin-releasing hormone (GnRH) through a process called negative feedback

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The schedule starts with daily shots for a week, then weekly for a month, and then monthly to keep it up

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Long-term monitoring is still advisable

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General pathophysiology of astroglia

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Long-term SFN use exhibited greater effectiveness, particularly in 786O cells, where the ST-SFN combination outperformed SFN alone [74]

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