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192 Additionally, mRNA therapy has been applied to treat patients with deficiencies in essential enzyme genes, such as argininosuccinate lyase, ornithine transcarbamylase, and methylmalonyl-CoA mutase (MUT), therefore restoring enzyme levels and mitigating deficiencies

Farias ICC, Mendona-Belmont TF, da Silva AS et al (2018) Association of the SOD2 polymorphism (Val16Ala) and SOD activity with vaso-occlusive crisis and acute splenic sequestration in children with sickle cell anemia

(2011), which established that the contents of glutamate and glutamine in cultured astrocytes increase by 50% in the presence of aspartate at a concentration of 100 M, but not in the presence of alanine or leucine

control) and synaptophysin (300% vs