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Cagrilintide, the second generation (2020s) Novo Nordisk took the Pramlintide concept and applied the same half-life extension strategy that they used with Semaglutide: Kept the proline substitutions (anti-amyloid) Added a C20 fatty diacid via a -Glu linker to a lysine residue, albumin binding Additionally stabilized the N- and C-terminal positions Result: Cagrilintide with a half-life of 6.6 days (vs 50 minutes for Pramlintide)

Marketing Authorization Holder GERDA LABORATORIES 24 RUE ERLANGER 75016 PARIS Operator of the marketing authorization GERDA LABORATORIES 24 RUE ERLANGER 75016 PARIS Maker DELPHARM TOURS LA BARAUDIERE 37170 CHAMBRAY LES TOURS or HAUPT PHARMA LIVRON 1 STREET COUNTY SINARD 26250 LIVRON-SUR-DROME Names of the drug in the member states of the European Economic Area Not applicable

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Research published in the Annals of the New York Academy of Sciences by Goldstein et al

Am I going to get sick? How do you respond without tearing up? McClendon told the Post