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Additionally, astrocyte-specific S1PR1 knockdown showed a protective effect against BIPN, suggesting that astrocytic S1PR1 plays a key role in BIPN pathogenesis (Stockstill et al., 2018)

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Most chemopreventive agents are currently in the preclinical research stage, and the preventive effects of natural compounds on cancer can be easily discovered in cell lines or animal models, however, it is difficult to apply the results as translational evidence for direct entry into clinical trials

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