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IGF-1 LR3 retains the pharmacological activity of IGF-1 as an agonist of the IGF-1 receptor while possessing significantly improved metabolic stability
J Thorac Cardiovasc Surg 130(6):1601-10, 2005

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The higher binding energy in solvent medium may be due to the fact that in aqueous medium the adduct species remain in the solvation state