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The incorporation of rotigotine into an extended-release microspheres (LY03003) was designed to overcome limitations associated with the existing rotigotine formulation, Neupro, a daily transdermal patch

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Time-related ChE activity in animals after administration of a single dose of dichlorvos --------------------------------------------------------------------------------------------------------- Species/sex Route Dose (mg/kg Time Cholinesterase activity (%) Reference body weight) plasma erythrocyte brain --------------------------------------------------------------------------------------------------------- Mouse (male) intraperitoneal 30 15 min 37 Cohen & Ehrich 2 h 40 (1976) 5 h 69 18 h 92 Mouse (male) intraperitoneal 10 15 min 30 Nordgren et al