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NF-B activation triggers its translocation to the cell nucleus, resulting in the upregulation of leukocyte adhesion molecules and cytokines that mediate leukocyte activation and recruitment [133]

Nausea (most common, especially during first 1 to 2 weeks of a new dose) Diarrhea or, just as often, constipation Vomiting (less common but more likely at 9 to 12 mg) Reduced appetite, food noise quieting down (this is the goal, not a side effect) Skin sensitivity (dysesthesia): tingling, prickly feeling, or sunburn-like skin

A small hole is drilled in the front of the humerus and the tendon stump is secured into the hole using a special interference screw

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