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Description
ATF4: Activating transcription factor 4
10 Correctors rescue protein folding, processing, and trafficking to a CFTR mutant and enhance protein stability
doi: 10.1105/tpc.113.111658 96 MannesA
System Clearance: Within 24 hours, a significant portion of the administered dose will likely be metabolized
Combining GPX4 and CDK4/6 inhibition leads to the collapse of the glutathione (GSH)-glutathione peroxidase 4 (GPX4) antioxidant systems that fails to protect against ferroptosis, and it is accompanied by a deep reduction of cell cycle and apoptosis markers 33,47,48
