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10.3390/ijms21155238 111 PatelJ

Phase 1 is activated by xenobiotics and carcinogens

For diluent selection, see bacteriostatic water vs sterile water

These include 1 ) the mitochondrial glycerol 3-phosphate dehydrogenase (G3PDH), a part of the glycerophosphate shuttle (75), 2 ) the mitochondrial dihydroorotate dehydrogenase (DHODH), an enzyme involved in a key step in the production of pyrimidine nucleotides (76), 3 ) the electron transport flavoprotein dehydrogenase (ETFDH), a key enzyme of fatty acid -oxidation and amino acid catabolism, 4 ) proline dehydrogenase (PRODH) and proline dehydrogenase 2 (PRODH2), both of which are involved in proline, glyoxylate, and arginine metabolism, 5 ) choline dehydrogenase (CHDH), which is primarily found in liver and kidney in humans and catalyzes the oxidation of choline to glycine betaine (77), and 6 ) sulfide-quinone oxidoreductase (SQOR), which is essential for detoxification of hydrogen sulfide (H 2 S) (78)

Over 400 different mold metabolites have been identified, however to date only several dozen have been shown to have significant toxic potency in humans