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The panel covers key steroid classes and pathway-associated metabolites, including estrogens, androgens, progestogens, glucocorticoids, mineralocorticoids, cholesterol, and other steroid hormone-related intermediates, enabling a more integrated view of steroid hormone biosynthesis

Several recent studies, including ones conducted in our department, revealed an association of acral melanoma on the plantar or palmar surfaces with mechanical or physical stress through anatomical mapping [15,47,48]

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Analyses of the misclassification cases also suggests that sequencing more than one region, predicting with more than one model, and taking majority vote will give maximal predictive accuracy (data not shown)

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