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Its small molecular size allows it to penetrate intestinal epithelial cells directly, which is why it has attracted research interest as an orally deliverable gut-targeted compound

Severe gastrointestinal problems, including changes in bowel habits, abdominal discomfort, blood in stools, or severe indigestion

Possible adverse effects may include: Injection site reactions : Redness, swelling, irritation, or discomfort Gastrointestinal symptoms : Nausea, vomiting, stomach cramps, or diarrhea Headaches or dizziness Allergic reactions : Rash, itching, shortness of breath, or facial swelling (rare) Increased heart rate or anxiety (typically temporary from B-vitamins) Fatigue or weakness if used improperly Elevated liver enzymes when taken in excess particularly with methionine or choline Insomnia if taken late in the day due to increased energy levels Who should avoid or use caution

We aimed to evaluate the relationship between baseline NLR levels and the efficacy and safety of tenecteplase in the Teneteplase Reperfusion Therapy in Acute Ischemic Cerebrovascular Events-III (TRACE-III) trial

Selmaj K, Raine CS, Farooq M, Norton WT, Brosnan CF