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Brains were extracted, post-fixed in 4% paraformaldehyde overnight, and then cryoprotected in 30% sucrose in 0.1 M phosphate buffer

Genotype-phenotype correlations do exist for some specific mutations, but these constitute the minority of cases [17]

Inositol 1,4,5-trisphosphate mobilizes intracellular Ca2+ from permeabilized insulin-secreting cells

doi: 10.1038/nm.3145

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