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A decrease in creatinine levels was noted at a higher dose of BPC 157, but not at lower doses, and animals recovered after a two-week withdrawal

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At the mechanistic level, BPC-157 appears to exert neural protective effects through interaction with multiple intracellular and signaling pathways

found that Notch inhibition increased hair cell regeneration by Lgr5 -positive cells in the neonatal cochlea in vitro (Bramhall et al., Lgr5 -positive cells, as the auditory and vestibular organs age