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Symptoms of MDD include a persistent sadness and low mood, anhedonia (loss of pleasure, loss of interest), irritability, low energy levels, altered appetite, and disrupted sleep [3]
Our results indicated that when used alone the three studied compounds are able to induce only a modest or null inhibition of TNF- activation of VCAM1 and a strong inhibition when used in combination, suggesting the presence of an additive effect of the three compounds
