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doi: 10.1155/2018/9041694 65

This phenomenon is known as the immunometabolic reprogramming of macrophages

[DOI] [PubMed] [Google Scholar] 86.Backe MB, Moen IW, Ellervik C, Hansen JB, Mandrup-Poulsen T

In terms of genotoxicity, comprehensive evaluations using both in vitro and in vivo methodologies have been conducted

Both paclitaxel and docetaxel are extensively metabolized, via cytochrome P 2C8 and 3A4, respectively, albeit pharmacological activity of these metabolites is modest at best and their contribution to the development of CIPN is unknown
