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Most hydrolyses occur to a significant extent in tissues other than liver

doi: 10.1007/s11901-018-0390-1 36

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Novel recombinant BCG expressing perfringolysin O and the over-expression of key immunodominant antigens

Taken together, these findings suggest that NSBSO-induced GSH depletion and synthesis inhibition can elevate intracellular ROS, thereby activating the caspase family, leading to GSDME cleavage and cell pyroptosis