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Clinically relevant NRF2-modulating agents currently include MMF (approved for relapsing forms of MS), diroximel fumarate (approved for relapsing forms of MS), tegomil fumarate (approved for RRMS by the EMA in 2025), and omaveloxolone (approved for Friedreichs ataxia

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doi: 10.1002/mnfr.201300334 67 KumarM.TomarM.PuniaS.Dhakane-LadJ.DhumalS.ChanganS.et al