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doi: 10.1007/s00775-005-0045-x 31

27 Depletion of parkinsonism-associated deglycase DJ-1, an oncogene located at 1P36.12-13 of human genome, reduced the activity of SAHH, thus leading to inhibition of transsulfuration pathway, enhancing the sensitivity of cancer cells to SLC7A11 inhibitor

Nonetheless, there are several overarching issues regarding DSNPs that should be considered in assessing these policy options

An additional remark is that tumour ascorbate levels, instead of plasma levels, might be more relevant to monitor treatment outcome

The pathways governing the H 2 O 2 decomposition reaction are comprehensively illustrated in Fig