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It is indeed well established that the subclinical inflammatory status induced by sleep deprivation has pathogenic implications for metabolic and CV risk factors (glucose metabolism, diabetes, hypertension, atherogenic lipid profile, endothelial dysfunction, and coronary calcification) and outcomes (stroke and coronary heart disease) 24

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It is stipulated that the combined content of emodin and emodin methyl ether should not be less than 0.1%, underscoring emodin as a crucial bioactive constituent responsible for the pharmacological effects of PMR

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