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Although primarily known as a pro-inflammatory cytokine that binds to cell membrane receptors to potentiate intracellular signaling 45 , eNAMPT can also be taken up by cells such as neurons and increase NAD + synthesis 46
Wu J, et al
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Future research needs to focus on the safety assessment and biocompatibility improvement of nanocarriers to ensure that efficacy is enhanced without introducing new safety risks
Targeting ROS-dependent pathways for drug development is challenging because of the dual role, complex regulation, and context-dependent activity of ROS
