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The first amylin agonist (pramlintide) was approved only for diabetes, requiring multiple daily injections and producing modest weight loss

The label expansion was supported by two Phase III trialsa 12-week induction study and a 52-week maintenance studyboth of which met the primary endpoint of clinical remission
The earliest theory proposed that mechanical factors lead to insufficient tendon repair and progressive cell death after injury to the tendon, which promote degeneration of the tendon

10.1177/2515690X211036875 [DOI] [PMC free article] [PubMed] [Google Scholar] 330.Yamamoto M, Kensler TW, Motohashi H