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10.1002/OPEN.202100159 35 SchioppaL.FallF.OrtizS.PoupaertJ

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The type I DGK, which includes the alpha, beta, and gamma isoforms, each contain two calcium-binding EF-hand motifs, which enable these isoforms to respond to Ca 2+ , in addition to the two C1 domains and the catalytic domain

The standard dose is 1.75 mg subcutaneously, taken 45 minutes before activity, with a limit of 1 dose per 24 hours and 8 per month

Although this trial did not meet its primary endpoint, exploratory analysis suggests that CSL112 may reduce cardiovascular death and myocardial, particularly in high-risk subgroups 108