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Microglia can be activated by cell-surface receptors for endotoxin, cytokines, chemokines, misfolded proteins, serum factors and ATP (Figure 1.6)

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Overall, microbially produced metabolites act as potent CNS regulators, either by modulating the vagus signaling and systemic immunity or by directly crossing the BBB ( 3.7.4 Radiation-induced injuries and microbial mediation Radiation-induced injuries initiate local and systemic responses, which are closely related to the gut microbiome's integrity