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Another mutation found in certain forms of hereditary hemochromatosis also affects the HFE gene and causes a change of His 63 to Asp (referred to as the H63D allele)

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These personalized regimens not only improve efficacy but also reduce adverse reactions by avoiding unsuitable therapies [228]

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In addition to other anti-inflammatory effects, colchicine has been shown to inhibit microtubule-driven spatial arrangement of mitochondria, thus preventing full NLRP3 inflammasome activation (65) and its use has been also reported to have beneficial effects in outpatients but not in hospitalized COVID-19 patients in recent clinical trials (6668)

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Du Plessis orcid.org/0000-0003-4617-4367 This article was submitted to Andrology, a section of the journal Frontiers in Reproductive Health Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Dexmedetomidine post-conditioning alleviates myocardial ischemia-reperfusion injury in rats by ferroptosis inhibition via SLC7A11/GPX4 axis activation

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