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Activation of the nuclear erythroid 2-related factor 2 antioxidant responsive element (Nrf2-ARE) signaling pathway alleviates acute graft-versus-host disease by reducing oxidative stress and inhibiting infiltration of inflammatory cells in an allogeneic stem cell transplantation mouse model

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The necessity to eradicate senescent cells in pathological contexts remains a high priority to develop innovative therapies in a large scale of diseases

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Post-mortem studies of the autistic brain samples showed abnormal changes in the steady-state levels of complexes I-IV in the cingulate gyrus, cerebellum, thalamus, and temporal and frontal cortex [79, 80, 86, 122]