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[Abstract] J Am Chem Soc

Ii H, Yoshiki T, Hoshiya N, Uenishi J

Characterization of vascular injury and endothelial dysfunction in microRNA-34a knockout mice with alcoholic steatohepatitis

doi: 10.1111/eci.12960

Irinotecan can be activated by carboxylesterase 1/2 (CES1/2) and catalyzed to a more active metabolite SN-38, both of which could form an inhibitory complex with TOP1 and DNA (Takano and Sugiyama, 2017)
