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Vitamin B12 deficiency has been linked to fatigue, tingling or loss of feeling in the extremities, irritability, memory impairment, depression, anemia, irritable bowel syndrome (IBS), constipation, poor wound healing, dry or damaged looking skin, and neurological disorders

Results from a 2017 study show an association with consuming high-dose B6 and B12 vitamin supplements over 10 years with an increase in lung cancer risk in men, especially smokers (Brasky, 2017)

[4] Clinical assessment should focus on identifying the cause of elevated levels rather than assuming toxicity from supplementation alone

2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society

When patients with hepatitis C were given standard therapy or standard therapy with a B12 injection of 5,000mcg, every 4 weeks for 48 weeks, those with the additional B12 responded better to treatment (18)