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Douglas KT: Mechanism of action of glutathione-dependent enzymes

GLP-1R agonists have demonstrated the ability to improve cognitive function, reduce hippocampal synaptic loss, and decrease A plaque deposition and A oligomer levels in APP/PS1 transgenic mice [53, 54]

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This genome-wide regulatory activity is unusual for such a small molecule and suggests GHK-Cu functions as a master regulatory switch in tissue homeostasis

Sirt3, the first deacetylase in the sirtuins family, is mostly present in the mitochondrial matrix and has a powerful protective effect on mitochondria (Zu et al., 2021)