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Pic C, Palou M, Pomar CA, Rodrguez AM, Palou A

doi: 10.1002/anie.201909052 148

In the 1980s, a pilot preclinical study on two rat and monkey PD models 16 and two independent clinical cases 17,18 showed that intracerebroventricular (i.c.v.) administration of dopamine improved motor symptoms, but also resulted in tachyphylaxia, possibly owing to dopamine oxidation despite the use of a preservative solution (sodium metabisulfite), precluding the therapeutic development of this concept

We propose that BxGST3 and BxGST1 support feeding and reproduction by detoxifying host defense compounds that would otherwise damage the nematodes digestive and reproductive tissues

Thirdly, the lack of effective and specific drugs that can safely induce ferroptosis in cancer cells poses an additional challenge