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When ACSL4 is upregulated, lipid peroxidation products and lethal reactive oxygen species accumulate, thus sensitiating lung cancer cells to ferroptosis [97, 98]

Noy R, Pollard JW

Among the top 20 most-enriched KEGG terms, the pathways most associated with hypoxic stress were p53 signaling pathway (ko04115), HIF-1 signaling pathway (ko04066), Glutathione metabolism signaling pathway (ko00480), FoxO signaling pathway (ko04068), and PI3K-Akt signaling pathway (ko04151) (Figure 4B)

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