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adhC and estD displayed an enhanced sensitivity to growth inhibition by exogenous formaldehyde but not other aldehydes or carbonyl compounds such as methylglyoxal ( estD mutant when compared with the adhC single mutant or the adhC-estD double mutant

Cytotoxicity assays were performed by co-culture of T cells with target cells at the indicated effector-to-target (E:T) ratios

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To date, we have learned that tirzepatide mainly stimulates insulin secretion through GIP receptor in human islets [149]

In addition, elevated GH in patients with poorly controlled type 1 diabetes mellitus was shown to induce podocyte injury and thereby may contribute to diabetic nephropathy