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Exogenous MT triggers the endogenous MT biosynthetic activity by up-regulating the expression of MT-biosynthetic genes (Ni et al
doi: 10.1002/em.21832
Permanent activation of Nrf2 by the genetic knockout of its negative regulator KEAP1 is extremely unfavorable for the organism: newborn knockout mice die quickly from starvation, most likely due to increased expression of -keratins and subsequent gastrointestinal keratosis [88]
In both men and women, proper thyroid function is necessary for healthy skin, hair, and nails
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