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SGLT2 is expressed nearly exclusively in the apical membranes of epithelial cells of the proximal tubule of the kidney and has been shown to be responsible for approximately 90% of the renal glucose reabsorption (see Figure below)

Furthermore, the activation of this signaling pathway by IGF-I can suppress -synuclein aggregation and toxicity, suggesting a possible therapeutically strategy in PD [130]

FerrDb: a manually curated resource for regulators and markers of ferroptosis and ferroptosis-disease associations

Model quality was assessed using R 2 X, R 2 Y, and Q 2 values, and 200 permutation tests were performed to evaluate overfitting

[DOI] [PMC free article] [PubMed] [Google Scholar] 232.Liochev SI