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Comment: Commenters expressed various concerns over the use of CAHPS Hospice Survey measures and the CAHPS Hospice Survey Index as an appropriate indicator in the proposed SFP algorithm, while also acknowledging the importance of including caregiver voices in the algorithm

Transporter-Mediated Prodrug Approach The transporter-mediated prodrug approach is based on delivery of the drug in the form of a prodrug, representing a substrate of the transporter, across the luminal and abluminal membranes of the brain capillary endothelial cells as well as the brain parenchymal cellular barrier followed by the release of the parent drug at the target site within the brain (Fig

These include: Nausea, vomiting, and diarrhoea (very common, especially during dose escalation) Reduced appetite and abdominal discomfort Constipation Risk of hypoglycaemia when used with insulin or sulphonylureas Pancreatitis and gallbladder disease have been reported Thyroid C-cell tumours have been observed in animal studies, though the relevance to humans is unknown Important safety considerations when using both treatments include: Mounjaro can reduce the effectiveness of oral contraceptives due to delayed gastric emptying

Therefore the brain is a major source of radicals derived from oxygen (Johnson et al

doi: 10.1158/0008-5472.CAN-23-0605 325 ShiQWangJZhouMZhengRZhangXLiuB
