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Subsequent examination of the best-performing dual-receptor inhibitors showed unique distributions of physicochemical properties (Fig

When highly oxidized proteins form crosslinked aggregates that are difficult to be degraded by the ubiquitinproteasome system, they are redirected to degradation by the autophagy system [107]

Moreover, advancements in drug delivery systems, such as niosomes, phytosomes, cubosomes, and transdermal patches, present improved opportunities for enhancing the bioavailability, solubility, and permeability of natural plant constituents used in the treatment of dental diseases (Das 2022)