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Although therapeutic options are available for chronic pain and depression, less than 50% of all patients treated for chronic pain report a clinically meaningful (i.e., 50%) pain relief with current analgesic treatments, and only about 5060% of patients with major depressive disorders achieved remission after an adequate course with conventional antidepressants

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Protein succinylation mediated by CPT1A has been demonstrated to promote the proliferation and invasion of gastric cancer (GC) by regulating LDHA succinylation

Therefore, a 1-week washout period was deemed sufficient to prevent carryover effects, consistent with protocols used in similar crossover designs involving acute L-carnitine supplementation

Cytokine storm, in tandem with lymphopenia, lymphocyte dysfunction, and granulocyte/ monocyte abnormalities, could increase the disease severity of COVID-19 222