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( 10.1007/BF03261931) [DOI] [PubMed] [Google Scholar] Rowe PJ, Comhaire FH, Hargreave TB, Mahmoud AMA.2000

ZieglerKAEngelhardtSCarnevaleDMcAlpineCSGuzikTJDimmelerSet alNeural mechanisms in cardiovascular health and disease
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Later, tramadol (100 mg) was tested in fibromyalgia in a randomized controlled trial [85] in a small group of patients

This condition is named cytopathic hypoxia. Cytopathic hypoxia during sepsis in a vicious cycle can lead to dysregulation in cellular energy production and the function of mitochondria along with worse outcomes for critically ill patients [9]
