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Lead (Pb) distorts the mechanism of neurotransmission (148) in the brain and causes variations in the regulation of hypothalamic neurotransmitters that affect the functional ability of gonadotropic hormones by influencing the control of the HPG axis (121, 149)

Research shows that reduced glutathione levels in the brain are linked to the development of neurological conditions

This neurodegeneration is accompanied by the formation of characteristic Lewy bodies, which are intracellular inclusions composed largely of aggregated and misfolded -synuclein ( This degeneration of dopaminergic neurons is strongly linked to the generation of reactive oxygen species and oxidative stress as well as mitochondrial dysfunction, neuroinflammation, and aging (Smeyne and Smeyne, 2013)

Bharali et al

Like other enzymes of the ascorbateglutathione cycle, APXs are also subjected to PTMs