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The leaving group in the conjugation of JS-K is 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate, which rapidly decomposes into 4-ethoxycarbonylpiperazine and the projected two active molecules of NO 8

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4 is the HPLC figure of the L-glutamic acid-alpha-tert-butyl ester provided in Example 1 of the present application

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