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Metabolism 92 , 170192

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In laboratory testing, it did not inhibit related SAM-dependent methyltransferases or interfere with other enzymes in NAD+ salvage pathways

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Fat that starts moving again

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5-amino-1MQ (5-amino-1-methylquinolinium iodide) is a small-molecule selective inhibitor of nicotinamide N-methyltransferase (NNMT), the enzyme that methylates nicotinamide using S-adenosylmethionine (SAM)

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Comprehensive biochemical testing demonstrates that 5 amino 1mq does not inhibit structurally similar methyltransferases, including catechol-O-methyltransferase (COMT), DNA methyltransferase 1 (DNMT1), or protein arginine methyltransferase 3 (PRMT3)

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