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It is known that activation of the ghrelin receptors in the pituitary gland causes elevated GH levels, which can positively impact body composition, such as by increasing lean mass

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Arbutin encapsulation within the transfersomes was resulted in augmented skin permeation and enhanced depigmenting effectiveness of the loaded drug (Wen et al., 2006b)

Amala Res Bull 15:4652 Joshi T, Singh AK, Haratipour P, Sah AN, Pandey AK, Naseri R, Juyal V, Farzaei MH (2019) Targeting AMPK signaling pathway by natural products for treatment of diabetes mellitus and its complications