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Low-dose lithium reduces NR2B subunit phosphorylation at the NMDA receptor, directly limiting calcium influx, and upregulates glutathione-dependent enzymes in animal models. Start at 5 mg daily

All patients were randomly divided into three groups by drawing lots and received three different medication treatments for 12 weeks

doi: 10.1016/j.bbabio.2008.11.003 48 Fisher-WellmanK

J Neurochem 66:18761881

Restoring adequate B12 levels in deficient individuals can improve energy levels and overall wellbeing, potentially making it easier to adhere to a structured weight loss programme involving dietary modification and exercise