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After stroke, autonomic imbalance can include relatively increased sympathetic drive with reduced parasympathetic (vagal) tone, which is linked to gastrointestinal dysmotility and may contribute to constipation, intestinal stasis, and conditions favoring bacterial overgrowth (

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Epithelial Smad4 Deletion Up-Regulates Inflammation and Promotes Inflammation-Associated Cancer

In contrast, ATP concentrations remained largely unchanged and thus did not significantly influence Hb oxygen affinity during short-term hypoxic exposure (Reference Woyke, Oberacher and Plunser67)

In animal models, it is relevant that doses of test agents (drugs/food supplements/herbal products) are at equivalent doses of what pertains to humans