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From a historical perspective, the risk of disease transmission from animal-derived collagen, particularly bovine spongiform encephalopathy (BSE), has also raised safety concerns [90]

Markus J, Mathiyalagan R, Kim YJ et al (2016) Intracellular synthesis of gold nanoparticles with antioxidant activity by probiotic Lactobacillus kimchicus DCY51T isolated from Korean kimchi

At this point, microglia becomes an unrestrained core of inflammatory mediators (e.g., cytokines and free radicals) that drive neuronal damage rather than exhibiting a repair-orientated profile ( As mentioned before, a broad number of data have shown that alcohol elevates inflammation in the brain, contributing to the impaired neurological function and neurodegeneration associated with alcohol consumption (Yakovleva et al., 2011)

[DOI] [PubMed] [Google Scholar] 108.Dixon S.J., Patel D.N., Welsch M., Skouta R., Lee E.D., Hayano M., Thomas A.G., Gleason C.E., Tatonetti N.P., Slusher B.S., et al

Hypoxic-ischemic injury in the developing brain: the role of reactive oxygen species originating in mitochondria
