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Next, we performed an extensive bioinformatics screen for putative cart sequences in various vertebrata genomes, including representatives of jawless vertebrates

Cells plated in glass-bottom 96-well plates were treated for the indicated times and, after fixation with 4% paraformaldehyde, images were acquired using a high-content microscope (Operetta, Perkin-Elmer)

However, this method of FXN rescue would not be beneficial for non-mitotic cells such as CNS neurons

The solution is stable under normal conditions when sealed

Hypersensitivity Reactions Hypersensitivity reactions, including anaphylaxis, have been reported in association with ACTEMRA and anaphylactic events with a fatal outcome have been reported with intravenous infusion of ACTEMRA