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Various pathogenic mechanisms and critical components have been reported, despite the fact that the origin is unknown, such as protein aggregation, iron buildup, mitochondrial dysfunction, neuroinflammation and oxidative stress

Finally, we discuss how individual variation arises and its consequences for one-carbon and glutathione metabolism

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The Journal of endocrinology , 165 (3), 569577.

For example, in pig production, if the feed contains excessive amounts of zinc, the activity of phytase in the digestive tract of pigs is inhibited, leading to lower phosphorus utilization and higher phosphorus excretion in feces [159]