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"Adipocyte apoptosis: a novel target for obesity therapy." Experimental & Molecular Medicine 52 (2020): 1039-1051

This can lead to a shorter duration of B12 in the body, increasing the need for supplementation or injections to maintain adequate levels
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The primary mechanism involves direct upregulation of vascular endothelial growth factor (VEGF) and VEGFR2 receptor expression a process documented across more than 40 individual published studies

Methylcobalamin is one of the biologically active forms of B12
