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Up- and down-regulation of microRNAs (miRNAs) can modulate the expression of target genes governing key signaling pathways responsible for melanoma progression ( Although there is still limited data on miRNA expression profiles in melanoma, techniques such as quantitative in situ hybridization (qISH) for fluorescent detection of candidate miRNAs, qRT-PCR, SplintR-qPCR , and miRNA microarray, have been employed to uncover differential miRNA expression levels in melanomas, in comparison to normal melanocytes and benign melanocytic lesions, as well as between primary and metastatic melanomas ( The deregulated expression of miRNAs leads to dysregulation of key signaling pathways controlling tumor cell proliferation, cell-to-cell interactions, epithelial-to-mesenchymal transition (EMT) ( Melanospheres express high levels of miR-10b, -21, -182-5p, -191-5p, -373, -378d, -520c, -542-3p, -1301, -1915-3p, -3934, -4767, which feasibly control their stemness and metastatic potential ( Frequent dysregulation of miRNA expression has been reported in association with the mutational status

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