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However, no targeted medications have been developed specifically for ASD (5)

Gomez-Bris R, Saez A, Herrero-Fernandez B, Rius C, Sanchez-Martinez H, Gonzalez-Granado JM

In: Handb Exp Pharmacol

Also, low bioavailability and rapid metabolism prevent the achievement of the pharmacologically relevant concentrations of the pharmacologically active compounds in preclinical studies

The intrinsic pathway of apoptosis is activated by stimuli that lead to the permeabilization of the OMM and the subsequent release of proteins from the mitochondrial IMS, such as cytochrome c (Martinou and Green, 2001
