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Interpreting limits of past ULT trials A guiding doctrine of the ACP guideline was that retrospective studies and even RCTs that used the decline in serum urate level to a pre-stipulated target as an indirect, surrogate outcome, rather than demonstrating the improvement in a clinical outcome such as reduction in frequency of acute gout flares during the randomized phase of an RCT, were insufficient data for the standard of evidence-based guidelines defined by the Institute of Medicine (since renamed the National Academy of Medicine) 40

10.1007/s11064-024-04163-3 151 ZilleM.KaruppagounderS

Also, a metabolomics study in China subsequently identified significantly lower levels of PA in patients with diabetes with nephropathy compared to patients with diabetes without complications 18

The role of fluorine in medicinal chemistry